Tires

Goodyear issued a bulletin on this subject so, I will answer by posting the actual text of the bulletin:
Nitrogen gas, as an inflation alternative to air, is becoming more prevalent in the market place and is being marketed as a benefit to the standard practice of using air to inflate tires.

Over a period of time both oxygen and nitrogen are able to penetrate through tire casings. However, oxygen molecules and nitrogen molecules are different sizes with oxygen being a smaller molecule than nitrogen. The size difference in the molecules allows the smaller oxygen molecule to permeate through the rubber at a more rapid rate.

Goodyear supports the use of nitrogen, as an inflation gas, in all Goodyear, Dunlop, Kelly, Associate Brand and Private Brand products, based on the ability for a tire to retain pressure for a longer period of time. The use of nitrogen will not affect the tire warranty.

Please be advised that even with the use of nitrogen as an inflation gas, regular inflation pressure checks are highly recommended.

By "over-the-road" I will assume you me line haul trucks. In this segment, the 295/75R22.5 size is by far the most popular, capturing 41% of the current original equipment market. Next is the 11R22.5 (23%), 11R24.5 (13%) in 4th place is the 285/75R24.5 size at 10%. Why? Over the last 10-15 year, has proven to be a the best compromise of fuel economy, handling and treadwear. Since it is the most popular (and growing each year), it would be my recommendation for new equipment for all the reasons I have given plus the fact that replacement tires should be easiest to find.

We suggest a non-water based commercial bead lubricant. However, thin vegetable oil soap solutions with water base are acceptable. Avoid the use of anti-freeze, silcones or petroleum based lubricants.

Speaking for Goodyear, the best product we make for spread axle trailers is actually a retread, the G119 SA (for spread axles). This retread was obviously designed specifically for this application. The fast wear factor is unavoidable for spread axle trailer tires so, we found that most opperators prefer a retread to lower the costs. The tread radius and shoulder design of the G119 SA is made to resist shoulder skirt tearing that often happens when new tires are used.

I can't say that changing sizes will help for sure but, going to a larger tire (bigger diameter and wider tread width) might help. I would suggest that you try our G670 RV tire (the G159's are no longer available). This tire was designed for motorhomes and should do a great job.